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Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours

Lookup NU author(s): Dr Evelyn Jaros, Emeritus Professor Robert Perry, Peter Crawford, Emeritus Professor David Mendelow, Professor Andrew Pearson


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The expression of p53 protein, epidermal growth factor receptor (EGFR), and Ki-67 nuclear antigen was examined by immunohistochemistry in biopsies of 16 types of human brain tumours, including 43 astrocytomas. P53 protein, almost certainly its mutant form, was expressed in seven of the 16, and EGFR in 11 of the 16 types of tumours. In astrocytomas both the proportion of tumours which expressed p53 or EGFR increased with grade of malignancy as did the mean Ki-67 labelleing index (LI): p53-0% in grade 1, 17% in grade 2, 38% in grade 3, 65% in grade 4; EGFR-0% in grade 1, 33% in grade 2, 85% in grade 3, 95% in grade 4; mean Ki-67 L1-1.1% in grades 1 and 2, 8.3% in grade 3, and 13.4% in grade 4. Astrocytomas which expressed p53 or EGFR had a significantly higher Ki-67 LI at P<0.05 (11.8% and 10.7%, resp.) than those that did not (6.2% or 4.1%, resp.). Patients with astrocytomas expressing p53 or EGFR had a significantly reduced survival (P = 0.035 and P = 0.007, resp.): only 11% of the p53 + ve and 13% of the EGFR + ve patients were alive at 100 weeks following diagnosis compared to 36% of p53-ve or 60% of EGFR-ve patients. Patients with Ki-67 LI > 5% had a reduced survival (P<0.0001) - none survived beyond 86 weeks following diagnosis, whilst 63% of patients with < 5% positive cells were still alive at 100 weeks. The univariate analysis showed that in astrocytomas expression of p53 mutants, EGFR protein, and Ki-67>5% are associated with malignant progression and poor prognosis. The multivariate analysis revealed that only tumour grade and Ki-67LI were independent prognostic factors for survival.

Publication metadata

Author(s): Jaros EAB, Perry RH, Adam L, Kelly PJ, Crawford PJ, Kalbag RM, Mendelow AD, Sengupta RP, Pearson ADJ

Publication type: Article

Publication status: Unknown

Journal: British Journal of Cancer

Year: 1992

Volume: 66

Issue: 2

Pages: 373-385

Print publication date: 01/08/1992

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

PubMed id: 1503912