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Nerve Growth Factor Receptor-Like Immunoreactivity in the Human Spinal Cord

Lookup NU author(s): Dr Janet Kerwin, Dr Christopher Morris, Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry


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Nerve growth factor (NGF) receptor-like immunoreactivity has been demonstrated in the normal human adult spinal cord using the monoclonal antibody ME20.4. Intense immunoreactivity was associated with fibres and terminals in the substantia gelatinosa. In lamina IX the neuropil demonstrated punctate staining, the motor neurons themselves being negative. At thoracic levels occasional neurons of the intermediolateral column cell group were NGF receptor positive. Fine axonal and punctate terminal reactivity was observed in the gracile fasciculus, corresponding to axons in transverse section. Similar, though slightly less dense immunoreactivity was observed in the cuneate fasciculus. The demonstration of NGF receptor immunoreactivity may provide a useful marker of sensory innervation in the human spinal cord.

Publication metadata

Author(s): Kerwin JM, Morris CM, Perry RH, Perry EK

Publication type: Article

Publication status: Published

Journal: Acta Anatomica

Year: 1992

Volume: 144

Issue: 4

Pages: 348-353

Print publication date: 01/08/1992

ISSN (print): 0001-5180

ISSN (electronic): 1421-9654

Publisher: S. Karger AG


DOI: 10.1159/000147329


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