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Interleukin-2 induction of lymphokine-activated killer activity in the peripheral blood of an acute lymphoblastic leukaemia patient - case study

Lookup NU author(s): Professor Anne Dickinson, Dr Anne Lennard, Dr Rosalind Cartner, Professor Stephen Proctor


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In this case study an acute lymphoblastic leukaemia (ALL) patient relapsing after autotransplant had remission reinduced with chemotherapy and consolidated after initial response by a course of therapy with recombinant interleukin-2 (rIL-2) given subcutaneously. Immunological parameters measured during therapy demonstrated an increase in the numbers of T cells and in lymphokine-activated killer (LAK) cell activity against autologous leukaemic blasts and LAK-sensitive cell lines. The therapy was well tolerated and administered on an out-patient basis. The patient has remained in haematological remission for over twelve months. Sustained remissions have not been observed previously in relapsed transplant patients using chemotherapy alone. The data suggests that rIL-2 deserves further evaluation in ALL patients who are immunologically intact with residual disease after primary or secondary chemotherapy.

Publication metadata

Author(s): Dickinson, A. M., Lennard, A. L., Cartner, R., Proctor, S. J.

Publication type: Article

Publication status: Published

Journal: Leukemia

Year: 1992

Volume: 6

Issue: 9

Pages: 957-960

Print publication date: 01/09/1992

ISSN (print): 0887-6924

ISSN (electronic): 1476-5551

PubMed id: 1518307