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Retinoblastoma and P53 gene expression related to relapse and survival in human breast cancer - an immunohistochemical study

Lookup NU author(s): Dr Brian Angus, Dr Christopher Wright, Professor Thomas Lennard, Dr Ian Corbett


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Inactivation of tumour suppressor genes may be an important aetiological factor in many human cancers including breast. In a study of 197 breast cancer patients, tumour tissue was snap-frozen at the time of surgery and immunohistochemical labelling for p53 protein and retinoblastoma (Rb) gene product carried out using an indirect immunohistochemical technique. Tumours were scored by two independent observers for the intensity of nuclear staining for each antibody. Expression of p53 protein showed a significant association with a shorter time to relapse (P=0-03) and death (P=0.02) (log rank test). p53 expression did not correlate with nodal status but showed a significant association with high tumour grade (P=0.001). Rb gene expression showed no relationship to relapse or survival but loss of expression showed a significant correlation with positive lymph node status. The manner by which these proteins might act to determine tumour behaviour remains to be established.

Publication metadata

Author(s): Sawan A, Randall B, Angus B, Wright C, Henry JA, Ostrowski J, Hennessy C, Lennard TWJ, Corbett IP, Horne CHW

Publication type: Article

Publication status: Published

Journal: Journal of Pathology

Year: 1992

Volume: 168

Issue: 1

Pages: 23-28

Print publication date: 01/09/1992

ISSN (print): 0022-3417

ISSN (electronic): 1096-9896


DOI: 10.1002/path.1711680105


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