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Prohibitive toxicity of a dose intense regime for metastatic neuroblastoma containing ifosfamide, doxorubicin and cisplatin

Lookup NU author(s): Professor Andrew Pearson, Dr Michael Reid, Emeritus Professor Alan Craft


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Three patients with stage 4 neuroblastoma were treated with a schedule comprising alternating modules of myelosuppressive (ifosfamide, etoposide, doxorubicin) and less myelosuppressive (vincristine, cisplatin) drugs given every 10 days regardless of the neutrophil count. A partial response was seen in two patients, and a very good partial response, in one patient. Extensive blood-component support was required. Non-haemopoietic toxicity was severe and led to treatment delays in two patients. Ifosfamide-related encephalopathy was seen in one patient and nephrotoxicity, in two patients. Mucositis was severe in two patients, may have contributed to the high rate of sepsis observed, and precluded the use of doxorubicin in one patient. As ifosfamide and doxorubicin were felt to be responsible for much of the toxicity, a subsequent schedule did not include these agents.

Publication metadata

Author(s): Lowis, S. P., Pearson, A. D. J., Reid, M. M., Craft, A. W.

Publication type: Note

Publication status: Published

Journal: Cancer Chemotherapy and Pharmacology

Year: 1993

Volume: 31

Issue: 5

Pages: 415-418

Print publication date: 01/09/1993

ISSN (print): 0344-5704

ISSN (electronic): 1432-0843


DOI: 10.1007/BF00686158

PubMed id: 8431977