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N-methyl-D-aspartate (NMDA) and non-NMDA binding sites in developing human frontal cortex

Lookup NU author(s): Dr Margaret Piggott, Emeritus Professor Elaine Perry, Emeritus Professor Robert Perry


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The binding levels of [H-3]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [H-3]kainate and [H-3](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10 -1min (MK-801) were examined in human frontal cortex homogenates ranging from 24 weeks gestation to old age. Different developmental profiles were revealed for each ligand. [H-3]kainate binding peaked sharply in the neonate, declining precipitantly during the first year and returning to foetal levels by the first or second decade, with no further decline. [H-3]AMPA binding was also highest in the neonate, declining by the first decade to foetal levels and showing little or no further decline. [H-3]MK-801 binding in the presence of glutamate, glycine and spermidine rose sharply from the foetal and neonatal stages to peak from about 3 months of age, with elevated binding until the first or second decade and a subsequent decline throughout the whole age range. The pronounced developmental peak in [H-3]kainate binding implicates this receptor in the organisation of neuronal pathways, and in vulnerability to hypoxia and ischaemia at birth.

Publication metadata

Author(s): Piggott MA, Perry EK, Perry RH, Scott D

Publication type: Article

Publication status: Published

Journal: Neuroscience Research Communications

Year: 1993

Volume: 12

Issue: 1

Pages: 9-16

Print publication date: 01/01/1993

ISSN (print): 0893-6609

ISSN (electronic): 1520-6769

Publisher: John Wiley & Sons Ltd