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Cytogenetic abnormalities in a disseminated medulloblastoma
Lookup NU author(s): Professor Andrew Pearson, John Emslie, Dr Anne Lennard, Emeritus Professor Robert Perry, Peter Crawford
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A 3-year-old girl developed central nervous system, bone and bone marrow metastases, and hypercalcaemia shortly after presentation with medulloblastoma. Cytogenetic studies of the involved bone marrow showed multiple abnormalities including iso(17q). This chromosome rearrangement has been reported in other cases of recurrent or disseminated medulloblastoma. More studies are required relating the karyotypes of medulloblastomas to long-term outcome to determine if the presence of iso(17q) is a prognostic factor in this malignancy.
Author(s): Stuart AG, Pearson ADJ, Emslie J, Lennard AL, Davison EV, Perry RH, Crawford PJ
Publication type: Article
Publication status: Unknown
Journal: Medical and Pediatric Oncology
Year: 1993
Volume: 21
Issue: 4
Pages: 295-298
Print publication date: 01/01/1993
ISSN (print): 1545-5009
ISSN (electronic): 1545-5017
