Browse by author
Lookup NU author(s): Professor Stephen Proctor
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
One hundred and eighteen patients presenting with high-grade non-Hodgkin's lymphoma, undergoing autologous bone marrow transplantation (ABMT) in first complete remission (CR), have been reported to the European Group for Bone Marrow Transplantation (EBMT). Of these, 102 were eligible for inclusion in this study following review of registration forms. Patients with lymphoblastic lymphoma were excluded. Remission induction and high-dose regimens varied between contributing centres. A maintained CR was observed in 90% of patients. Early relapse was observed in 6%, and 4% suffered toxic deaths. With a median follow-up of 45 months (3-112 months), the 5-year actuarial overall and progression-free survivals are both 70%. Nineteen (18%) patients relapsed at a median of 3.5 months (0.25-52 months) after ABMT, only 1 achieving a further durable CR. The only factor with prognostic significance was histological subtype, with diffuse small noncleaved-cell lymphoma having a significantly worse outcome. High-dose therapy and ABMT has produced effective consolidation of first remission in this group of patients, even in those with poor prognostic features at presentation.
Author(s): Sweetenham JW, Proctor SJ, Blaise D, Laurenzia A, Pearce R, Taghipour G, Goldstone AH
Publication type: Article
Publication status: Published
Journal: Annals of Oncology
Year: 1994
Volume: 5
Issue: Suppl. 2
Pages: S155-S159
Print publication date: 01/01/1994
ISSN (print): 0923-7534
ISSN (electronic): 1569-8041
