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Rapid detection of prognostic genetic factors in neuroblastoma using fluorescence in situ hybridisation on tumour imprints and bone marrow smears. United Kingdom Children's Cancer Study Group

Lookup NU author(s): Dr Nicholas Bown, Dr Michael Reid, Professor Archibald Malcolm, Professor Andrew Pearson


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A number of biological Factors have been identified which correlate with prognosis in neuroblastoma. Among these are genetic aberrations, including ploidy, deletions of chromosome 1p and N-myc amplification. Conventional methods of detecting these changes, such as tissue culture for karyotyping and Southern blotting, are time-consuming and yield interpretable results in only a small proportion of cases. We have developed interphase fluorescence in situ hybridisation for use on tumour imprints and bone marrow smears, allowing rapid visualisation of the relevant genetic changes. Valuable prognostic information is therefore available in a few days: the results in our cases were later confirmed by conventional methods. In the foreseeable future it will be possible to define distinct prognostic categories on the basis both of this genetic information and other parameters, and separate therapeutic strategies may then be employed for the different patient groups.

Publication metadata

Author(s): Taylor CPF, McGuckin AG, Bown NP, Reid MM, Malcolm AJ, Pearson ADJ, Sheer D

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1994

Volume: 69

Issue: 3

Pages: 445-451

Print publication date: 01/03/1994

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

PubMed id: 8123471


Funder referenceFunder name
A3585Cancer Research UK