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Lookup NU author(s): Dr Andrew Hall,
Professor Andrew Pearson,
Professor Archibald Malcolm,
Dr Michael Reid
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Antisera to each of the three main cytosolic forms of glutathione S-transferase (GST; alpha, mu, and pi) has been used to characterise GST expression by metastatic neuroblastoma in bone marrow trephine biopsies taken from 15 patients at presentation and from five of this group at relapse. There was no correlation between expression of extranuclear alpha or mu GST and outcome, and no consistent pattern at relapse. Seven of eight expressing nuclear pi GST at presentation died of resistant disease. Three of five cases with no detectable nuclear pi class GST remain alive and disease free. The results provide no encouragement for further investigation of alpha or mu GST in this disease but larger studies of uniformly treated patients may show whether nuclear pi GST expression at presentation indicates likely relapse.
Author(s): Hall AG, McGuckin AG, Pearson ADJ, Cattan AR, Malcolm AJ, Reid MM
Publication type: Note
Publication status: Published
Journal: Journal of Clinical Pathology
Print publication date: 01/05/1994
ISSN (print): 0021-9746
ISSN (electronic): 1472-4146
PubMed id: 8027404