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Glutathione S-transferase in bone marrow metastases of disseminated neuroblastoma

Lookup NU author(s): Dr Andrew Hall, Professor Andrew Pearson, Professor Archibald Malcolm, Dr Michael Reid


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Antisera to each of the three main cytosolic forms of glutathione S-transferase (GST; alpha, mu, and pi) has been used to characterise GST expression by metastatic neuroblastoma in bone marrow trephine biopsies taken from 15 patients at presentation and from five of this group at relapse. There was no correlation between expression of extranuclear alpha or mu GST and outcome, and no consistent pattern at relapse. Seven of eight expressing nuclear pi GST at presentation died of resistant disease. Three of five cases with no detectable nuclear pi class GST remain alive and disease free. The results provide no encouragement for further investigation of alpha or mu GST in this disease but larger studies of uniformly treated patients may show whether nuclear pi GST expression at presentation indicates likely relapse.

Publication metadata

Author(s): Hall AG, McGuckin AG, Pearson ADJ, Cattan AR, Malcolm AJ, Reid MM

Publication type: Note

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 1994

Volume: 47

Issue: 5

Pages: 468-469

Print publication date: 01/05/1994

ISSN (print): 0021-9746

ISSN (electronic): 1472-4146


DOI: 10.1136/jcp.47.5.468

PubMed id: 8027404