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Lookup NU author(s): Professor Herbie Newell
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Background: The exploitation of pharmacokinetic-pharmacodynamic relationships is worthwhile for drugs where there is difficulty or delay in obtaining clinical evidence of therapeutic or toxic effects, where there is a clear relationship between the pharmacokinetics and pharmacodynamics, and where the drug has a small therapeutic index. These criteria are amply met by cytotoxic anticancer agents. In particular, an extensive literature for all classes of cancer chemotherapeutics shows that the correlation between pharmacokinetic parameters (peak concentration, area under the plasma concentration-time curve, clearance or steady-state levels) and toxicity is in many cases better than the relationship between dose and toxicity. Adaptive dosing: Prospective studies of dose adaptation on the basis of pharmacokinetic or pharmacodynamic information, with or without feedback control, have shown that pharmacologically guided dosing is feasible. Adaptive dosing results in reduced pharmacokinetic variability and more consistent toxicity. Currently, there are insufficient prospective studies to allow conclusions concerning the efficacy of such a dosing system.
Author(s): Newell DR
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Meeting on Recent Advances in the Biology and Treatment of Solid Tumours
Year of Conference: 1994
Pages: S9-S15
Publisher: Annals of Oncology: Oxford University Press
PubMed id: 8060901
Library holdings: Search Newcastle University Library for this item
ISBN:
