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Autologous bone marrow transplantation in acute lymphoblastic leukaemia

Lookup NU author(s): Professor Graham Jackson, Dr Penelope Taylor, Dr Anne Lennard, Professor Stephen Proctor


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There has been a great deal of interest in the use of high dose chemotherapy and/or radiotherapy, with autologous bone marrow/peripheral blood stem cell rescue, in the treatment of haematological malignancies including acute lymphoblastic leukaemia (ALL). In this review we assess the role of autologous bone marrow transplantation (ABMT) in ALL. The heterogeneity of this disease makes the analysis of treatment results in ALL difficult to interpret. There is some evidence that ABMT may be useful in second complete remission (CR) and increasing interest in ABMT as a therapeutic option in first CR in adults. At the moment there is little evidence that such an approach will have an impact in childhood ALL. ABMT is considerably less toxic than allogeneic bone marrow transplantation and the major cause of 'treatment failure' is disease relapse. There has been considerable effort put into purging autologous bone marrow of malignant stem cells but whether purging is effective remains controversial and not proven. Newer studies involving cytokines post-ABMT to stimulate an artificial 'graft versus leukaemia' effect may prove of value.

Publication metadata

Author(s): Jackson, G. H., Taylor, P. R. A., Lennard, A. L., Proctor, S. J.

Publication type: Article

Publication status: Published

Journal: Blood Reviews

Year: 1994

Volume: 8

Issue: 3

Pages: 161-168

Print publication date: 01/09/1994

ISSN (print): 0268-960X

ISSN (electronic): 1532-1681


DOI: 10.1016/0268-960X(94)90077-U


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