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Dose optimization of carboplatin in adults

Lookup NU author(s): Professor Alan Calvert

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Abstract

Carboplatin haematological toxicities are clearly related to AUC. It seems likely that therapeutic efficacy is also related to AUC, although the maturation of clinical trials is necessary to establish this point. Using AUG-based dosing compensates for variations in renal function between and within individual patients. Since this variability is considerable, AUG-based dosing is a desirable practice. However; it does not allow for other factors such as previous chemotherapy, previous radiotherapy or performance status. Thus it does not remove the Requirement for clinical judgements when managing a patient with cancer; it simply helps to remove one of the subjective elements of such judgements.


Publication metadata

Author(s): Calvert, A. H.

Publication type: Article

Publication status: Published

Journal: Anticancer Research

Year: 1994

Volume: 14

Issue: 6A

Pages: 2273-2277

Print publication date: 01/11/1994

ISSN (print): 0250-7005

ISSN (electronic): 1791-7530

Notes: Originally presented at the 5th Conference on Oncological Clinical Pharmacology, 08/10-11-1994, Reims, France.


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