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Concentrations of soluble vascular cell adhesion molecule-1 and E-selectin in breast cyst fluid and their relation with cyst type
Lookup NU author(s): Professor Thomas Lennard
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Gross cystic breast disease may be associated with a higher risk of breast cancer. There are two groups of mammary cysts: those lined by aprocrine epithelium (intracystic sodium to postassium (Na:K) ratio < 3) and those lined by flattened epithelium (intracystic Na:K ratio > 3. Cell adhesion molecules may be involved in various stages of tumour metastsis. Intracystic levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) were measured. Significantly greater concentrations of sVCAM-1 and sE-selectin occurred in the high-electrolyte ratio group than in the low (P < 0.001). A positive correlation was found between sVCAM-1 and sE-selectin (r(s) = 0.827, P < 0.001) which may be a chance observation or suggest a common mechanism of entry into mammary cysts. The significance of these soluble cell adhesion molecules in breast cyst fluid requires elucidation.
Author(s): Lai LC, Siraj AK, Kadory S, Lennard TWJ
Publication type: Article
Publication status: Published
Journal: British Journal of Surgery
Year: 1995
Volume: 82
Issue: 1
Pages: 83-85
Print publication date: 01/01/1995
ISSN (print): 0007-1323
ISSN (electronic): 1365-2168
URL: http://dx.doi.org/10.1002/bjs.1800820129
DOI: 10.1002/bjs.1800820129
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