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Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma

Lookup NU author(s): Dr Richard Gilbertson, Professor Andrew Pearson, Emeritus Professor Robert Perry, Dr Evelyn Jaros


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The expression and prognostic significance of the c-erbB-2 oncogene product was studied in 55 cases of childhood medulloblastoma. Forty-six of the 55 tumours (83.6%) expressed the c-erbB-2 product. The percentage of tumour cells expressing the c-erbB-2 product proved to be a significant indicator of patient outcome when analysed as both a categorical and a continuous variable. As a categorical variable, patients with more than 50% positive tumour cells had a significantly worse survival, with only 10% alive at 10 years vs 48% for those with less than 50% positive tumour cells (log rank P = 0.0049). To demonstrate that this observed prognostic significance was both independent and not a result of 'data-driven' categorisation, it was also entered into the Cox model as a continuous variable. Prognostic significance was retained with P = 0.038.

Publication metadata

Author(s): Gilbertson RJ, Pearson ADJ, Perry RH, Jaros EAB, Kelly PJ

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1995

Volume: 71

Issue: 3

Pages: 473-477

Print publication date: 01/03/1995

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

PubMed id: 7880726