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Lookup NU author(s): Professor Zofia Chrzanowska-Lightowlers,
Professor Robert Lightowlers
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Expression of the liver-type isopeptides of cytochrome c oxidase is regulated post-transcriptionally. An RNA-binding activity has been found in only those cells where the liver-type subunits are detected, This binding protein, termed COLBP, recognises sequences or structures within the 3'-untranslated regions of transcripts encoding these liver-type isopeptides and has been implicated in the modulation of mRNA expression, We now show by subcellular fractionation, immunocompetition, UV-crosslinking and shift-Western studies that the metabolic enzyme glutamate dehydrogenase, previously reported as being able to bind RNA, is the cytochrome c oxidase transcript-binding protein, COLBP.
Author(s): Preiss T, Sang AE, Chrzanowska-Lightowlers ZMA, Lightowlers RN
Publication type: Article
Publication status: Published
Journal: FEBS Letters
Print publication date: 01/07/1995
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
Publisher: Elsevier BV
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