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Lookup NU author(s): Emeritus Professor Alan MurrayORCiD
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Introduction: Ventricular fibrillation is a most dangerous cardiac arrhythmia that has received considerable attention, yet its pattern of electrical activation remains controversial. The aim of this study was to investigate the degree of organization during the clinical arrhythmia and to examine the phase relationship between deflections in independent ECG leads. Methods and Results: Ten recordings of ventricular fibrillation were examined, Each had been provoked during routine electrophysiological study. The mean duration of ventricular fibrillation was 21 seconds (range 11 to 34), Independent and approximately orthogonal ECG leads I, a VF, and V-2 were recorded to computer at a sampling rate of 250 Hz. The phase relationship of each ECG lead pair was measured from the lag of peaks in their cross-correlation function (CCF), In 61% of the 1-second ECG epochs analyzed, CCF peak lag changed by < 20 msec compared to the previous epoch, Thus, the overall phase relationship was stable most of the time, Changes in CCF peak lag tended to be either gradual or to punctuate periods of stability. Conclusions: This study provides evidence of organized myocardial activation during human ventricular fibrillation.
Author(s): CLAYTON RH, MURRAY A, CAMPBELL RWF
Publication type: Article
Publication status: Published
Journal: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
Print publication date: 01/08/1995