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Clinical impact of colonoscopic screening in first‐degree relatives of patients with hereditary non‐polyposis colorectal cancer

Lookup NU author(s): Professor Sir John BurnORCiD


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Sixty-one asymptomatic individuals with an affected first-degree relative from five large hereditary non-polyposis colorectal cancer (HNPCC) kindreds were screened by colonoscopy. Neoplasms were found in nine (15 per cent) of 61 individuals on the first screen. Five subjects had a single adenoma while two had two adenomas each. There were two patients (3 per cent) with malignant neoplasms: one with a Dukes B adenocarcinoma and one with synchronous Dukes C adenocarcinomas in the caecum and ascending colon. These findings support the hypothesis that adenomas do not occur in large numbers in HNPCC families but, because of the high malignant conversion rate, biennial colonoscopy with removal of polyps seen is recommended.

Publication metadata

Author(s): Green SE, Chapman PD, Burn J, Bishop DT, Varma JS

Publication type: Article

Publication status: Published

Journal: British Journal of Surgery

Year: 1995

Volume: 82

Issue: 10

Pages: 1338-1340

Print publication date: 05/12/1995

ISSN (print):

ISSN (electronic):


DOI: 10.1002/bjs.1800821013


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