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Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease

Lookup NU author(s): Alan Leake, Emeritus Professor Robert Perry, Professor Ian McKeith, Professor Jim Edwardson, Dr Christopher Morris


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Apolipoprotein E (APO E) genotypes were determined in a UK population of neuropathologically confirmed control cases, and in cases of Lewy body dementia (SDLT) and late onset Alzheimer's disease (AD). APO E epsilon 4 allele frequency was significantly elevated in both SDLT and AD groups with a concomitant reduction in the APO E epsilon 3 allele frequency. The epsilon 2 allele frequency in the AD group was only 25% of the control population, though because of the relatively small sample size this reduction was not significant; the epsilon 2 allele frequency in the SDLT group was normal. No significant association was found between senile plaque density and neurofibrillary tangle density in the neocortex and APO E allele dose in either SDLT or AD. Although the possession of APO E epsilon 4 is associated with an increased risk of developing SDLT and AD, actual APO E genotype does not appear to affect the burden of pathology. (C) 1995 Academic Press Limited.

Publication metadata

Author(s): McKeith IG; Edwardson JA; Perry RH; Leake A; Morris CM; Benjamin R; Ince PG

Publication type: Article

Publication status: Published

Journal: Neurodegeneration

Year: 1995

Volume: 4

Issue: 4

Pages: 443-448

Print publication date: 01/12/1995

ISSN (print): 1055-8330

ISSN (electronic): 1522-9661

Publisher: Academic Press


DOI: 10.1006/neur.1995.0053


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