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Abnormally phosphorylated tau protein in senile dementia of Lewy body type and Alzheimer disease: Evidence that the disorders are distinct

Lookup NU author(s): Emeritus Professor Robert Perry, Emeritus Professor Elaine Perry


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The relationship between Alzheimer disease (AD) and dementia with Lewy bodies (senile dementia Lewy body type, or SDLT) and dementia in Parkinson's disease is unclear. AD pathology is characterised by both amyloid deposition and abnormal phosphorylation of tau in paired helical filaments (PHF-tau). In AD, abnormally phosphorylated PHF-tau is present in neurofibrillary tangles, in neuritic processes of senile plaques, and also in neuropil threads dispersed throughout the cerebral cortex. Cortical homogenates from 12 cases each of AD and SDLT, 13 cases of Parkinson's disease, and 11 normal controls were examined by Western blot analysis with antibodies that detect PHF-tau. No PHF-tau was found in Parkinson's disease or control cortex. No PHF-tau was found in SDLT cases without histological evidence of tangles. PHF-tau was detectable in SDLT cases with a low density of tangles, and large amounts of PHF-tau were present in AD cases. This study demonstrates that abnormally phosphorylated PHF-tau is only present where tangles are found and not in SDLT cases without tangles or with only occasional tangles. It is concluded that Lewy body dementias are distinct at a molecular level from AD.

Publication metadata

Author(s): Perry RH; Perry EK; Strong C; Anderton BH; Ince PG; Lovestone S

Publication type: Article

Publication status: Published

Journal: Alzheimer Disease & Associated Disorders

Year: 1995

Volume: 9

Issue: 4

Pages: 218-222

Print publication date: 01/11/1995

ISSN (print): 0893-0341

ISSN (electronic): 1546-4156

Publisher: Lippincott Williams & Wilkins