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C-erbB-2 in bladder cancer: Molecular biology, correlation with epidermal growth factor receptors and prognostic value

Lookup NU author(s): Kilian Mellon, Professor John LunecORCiD, Dr Christopher Wright, Professor David Neal


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Purpose: To study the c-erbB-2 oncogene in primary transitional cell bladder cancer. Materials and Methods: Ninety-five patients with known clinical follow-up and epidermal growth factor receptor (EGFr) status were studied for expression of c-erbB-2 by immunostaining. Possible mechanisms underlying increased staining for c-erbB-2 protein were investigated by analyzing DNA and RNA encoding c-erbB-2. Results: Strong positive staining for c-erbB-2 was detected in 20 (21%) tumors, with weaker staining in a further 13 (14%). There was no correlation between increased staining for c-erbB-2 and tumor stage, grade, or EGFr status. There was a low rate of amplification of the c-erbB-2 gene (1 of 24) on Southern blotting with a higher rate of elevated c-erbB-2 mRNA (4 of 44) with dot blot hybridization. For pT1 tumors, the rate of recurrence was higher for those tumors which were positive for c-erbB-2. Conclusions: c-erbB-2 oncoprotein is expressed by a significant proportion of transitional cell tumors of the bladder. In this study, the prognostic significance of c-erbB-2 expression appears limited.

Publication metadata

Author(s): Mellon, J.K., Lunec, J., Wright, C., Horne, C.H.W., Kelly, P., Neal, D.E.

Publication type: Article

Publication status: Unknown

Journal: Journal of Urology

Year: 1996

Volume: 155

Issue: 1

Pages: 321-326

Print publication date: 01/01/1996

ISSN (print): 0022-5347

ISSN (electronic): 1527-3792