Toggle Main Menu Toggle Search

Open Access padlockePrints

C-erbB-2 in bladder cancer: Molecular biology, correlation with epidermal growth factor receptors and prognostic value

Lookup NU author(s): Kilian Mellon, Professor John LunecORCiD, Dr Christopher Wright, Professor David Neal

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Purpose: To study the c-erbB-2 oncogene in primary transitional cell bladder cancer. Materials and Methods: Ninety-five patients with known clinical follow-up and epidermal growth factor receptor (EGFr) status were studied for expression of c-erbB-2 by immunostaining. Possible mechanisms underlying increased staining for c-erbB-2 protein were investigated by analyzing DNA and RNA encoding c-erbB-2. Results: Strong positive staining for c-erbB-2 was detected in 20 (21%) tumors, with weaker staining in a further 13 (14%). There was no correlation between increased staining for c-erbB-2 and tumor stage, grade, or EGFr status. There was a low rate of amplification of the c-erbB-2 gene (1 of 24) on Southern blotting with a higher rate of elevated c-erbB-2 mRNA (4 of 44) with dot blot hybridization. For pT1 tumors, the rate of recurrence was higher for those tumors which were positive for c-erbB-2. Conclusions: c-erbB-2 oncoprotein is expressed by a significant proportion of transitional cell tumors of the bladder. In this study, the prognostic significance of c-erbB-2 expression appears limited.


Publication metadata

Author(s): Mellon, J.K., Lunec, J., Wright, C., Horne, C.H.W., Kelly, P., Neal, D.E.

Publication type: Article

Publication status: Unknown

Journal: Journal of Urology

Year: 1996

Volume: 155

Issue: 1

Pages: 321-326

Print publication date: 01/01/1996

ISSN (print): 0022-5347

ISSN (electronic): 1527-3792


Share