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Disseminated BCG infection in severe combined immunodeficiency presenting with severe anaemia and associated with gross hypersplenism after bone marrow transplantation

Lookup NU author(s): Professor Roderick Skinner, Dr Michael Barer, Professor John Magee, Dr Mario Abinun, Professor Andrew Cant


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An infant with severe combined immunodeficiency (SCID) is described, who presented with severe anaemia and hepatosplenomegaly due to disseminated Bacillus Calmette-Guerin (BCG) infection involving the bone marrow, liver and spleen, After BMT, huge splenic enlargement occurred, presumably due to proliferation of engrafted donor Lymphocytes, leading to severe hypersplenism. Peripheral blood cell consumption was resolved by splenectomy, but gradual loss of the marrow graft followed.

Publication metadata

Author(s): Skinner R, Appleton AL, Sprott MS, Barer MR, Magee JG, Darbyshire PJ, Abinun M, Cant AJ

Publication type: Article

Publication status: Published

Journal: Bone Marrow Transplantation

Year: 1996

Volume: 17

Issue: 5

Pages: 877-880

Print publication date: 01/05/1996

ISSN (print): 0268-3369

ISSN (electronic): 1476-5365