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Lookup NU author(s): Professor Roderick Skinner,
Dr Michael Barer,
Professor John Magee,
Dr Mario Abinun,
Professor Andrew Cant
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An infant with severe combined immunodeficiency (SCID) is described, who presented with severe anaemia and hepatosplenomegaly due to disseminated Bacillus Calmette-Guerin (BCG) infection involving the bone marrow, liver and spleen, After BMT, huge splenic enlargement occurred, presumably due to proliferation of engrafted donor Lymphocytes, leading to severe hypersplenism. Peripheral blood cell consumption was resolved by splenectomy, but gradual loss of the marrow graft followed.
Author(s): Skinner R, Appleton AL, Sprott MS, Barer MR, Magee JG, Darbyshire PJ, Abinun M, Cant AJ
Publication type: Article
Publication status: Published
Journal: Bone Marrow Transplantation
Print publication date: 01/05/1996
ISSN (print): 0268-3369
ISSN (electronic): 1476-5365