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Lookup NU author(s): Professor Jim Edwardson,
Emeritus Professor Robert Perry,
Professor Ian McKeith,
Dr Christopher Morris,
Dr David Neill
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HLA-DR antigen types were determined from DNA isolated from post-mortem brain tissue of age-matched groups of 78 patients with pathologically confirmed late-onset Alzheimer's disease (AD) and 50 controls. The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD. Conversely the DR4 or 6 antigens are associated with a decreased risk of similar magnitude. This DR effect, rather than prolonged use of non-steroidal anti-inflammatory drugs, could be responsible for the reported lower prevalence of AD in rheumatoid arthritis (a condition associated with an increased frequency of DR-4).
Author(s): McKeith I; Edwardson J; Perry R; Morris C; Neill D; Curran M; Middleton D
Publication type: Article
Publication status: Published
Print publication date: 01/04/1997
ISSN (print): 0959-4965
ISSN (electronic): 1473-558X
Publisher: Lippincott Williams & Wilkins
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