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HLA-DR antigens associated with major genetic risk for late-onset Alzheimer's disease

Lookup NU author(s): Professor Jim Edwardson, Emeritus Professor Robert Perry, Professor Ian McKeith, Dr Christopher Morris, Dr David Neill


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HLA-DR antigen types were determined from DNA isolated from post-mortem brain tissue of age-matched groups of 78 patients with pathologically confirmed late-onset Alzheimer's disease (AD) and 50 controls. The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD. Conversely the DR4 or 6 antigens are associated with a decreased risk of similar magnitude. This DR effect, rather than prolonged use of non-steroidal anti-inflammatory drugs, could be responsible for the reported lower prevalence of AD in rheumatoid arthritis (a condition associated with an increased frequency of DR-4).

Publication metadata

Author(s): McKeith I; Edwardson J; Perry R; Morris C; Neill D; Curran M; Middleton D

Publication type: Article

Publication status: Published

Journal: NeuroReport

Year: 1997

Volume: 8

Issue: 6

Pages: 1467-1469

Print publication date: 01/04/1997

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/00001756-199704140-00028


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