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Lookup NU author(s): Emeritus Professor Alan Craft,
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The aim of this study was to evaluate multimodal chemotherapy and radiotherapy in patients with Ewing's sarcoma. 142 (74 male, 68 female) patients were entered into the ET-1 study between 1978 and 1986. They were treated with vincristine, doxorubicin, actinomycin D, and cyclophosphamide with radiotherapy plus or minus surgery to the primary tumour. Of the 120 who had no metastases at diagnosis, 45 remain alive with a median follow-up of 11.2 years. Only 2 of those with metastases at diagnosis remain alive. The major prognostic factor was site of disease, but age and serum lactic dehydrogenase at diagnosis also had an influence on outcome. 45 of the 61 patients who survived 4 years or more had late effects documented. The type and extent were dependent on tumour site, type of local therapy, volume and dose of radiotherapy. 4 patients had second malignancies. Prospects for long-term survival have improved in patients treated for Ewing's sarcoma. However, late sequelae are present in the majority of patients. (C) 1997 Elsevier Science Ltd.
Author(s): Craft, A. W., Cotterill, S. J., Bullimore, J. A., Pearson, D.
Publication type: Article
Publication status: Published
Journal: European Journal of Cancer
Print publication date: 01/06/1997
ISSN (print): 0959-8049
ISSN (electronic): 1879-0852
PubMed id: 9376188
Notes: United Kingdom Children's Cancer Study Group (UKCCSG) and the Medical Research Council Bone Sarcoma Working Party.
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