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Importance of neurological assessment before bone marrow transplantation for osteopetrosis

Lookup NU author(s): Dr Mario Abinun, Professor Andrew Cant


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Neurological complications of malignant infantile osteopetrosis are well recognised; successful bone marrow transplantation, when performed early in life, can prevent or halt some of them. In a subgroup of infants osteopetrosis is associated with primary retinal degeneration and/or generalised neurodegeneration. Bone marrow transplantation, in spite of being successful in correcting the osseous and haematological abnormalities, does not influence the progressive course of the neurodegenerative disorder. Thus, the recognition of this subgroup of infants with a very poor prognosis is essential before deciding on bone marrow transplantation.

Publication metadata

Author(s): Abinun M, Newson T, Rowe PW, Flood TJ, Cant AJ

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 1999

Volume: 80

Issue: 3

Pages: 273-274

Print publication date: 01/03/1999

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Group


DOI: 10.1136/adc.80.3.273


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