Toggle Main Menu Toggle Search

Open Access padlockePrints

Adipocyte insulin action following ovulation in polycystic ovarian syndrome

Lookup NU author(s): Professor Alison Murdoch, Professor Roy Taylor

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

The role of anovulation and insulin resistance in the pathogenesis of polycystic ovarian syndrome (PCOS) remains to be determined. The aim of this study was to investigate whether the metabolic abnormality of insulin resistance in PCOS reflects, rather than causes, the ovarian dysfunction. Eight subjects with classical PCOS were studied on two occasions. Adipocyte insulin sensitivity together with hormonal and metabolic changes mere investigated in patients with PCOS following prolonged amenorrhoea and then again in the early follicular phase after ovulation. Insulin receptor binding in amenorrhoeic subjects with PCOS was low at 0.78 +/- 0.08% and this increased to 1.18 +/- 0.19% after an ovulatory cycle (P < 0.05). Maximal insulin stimulated 3-O-methylglucose uptake was 0.70 +/- 0.14 during amenorrhoea and increased to 1.08 +/- 0.25 pmol/10 cm(2) cell membrane (P < 0.05). Plasma testosterone fell (4.0 +/- 0.4 to 2.3 +/- 0.2 nmol/l; P < 0.001), luteinizing hormone feb (17.6 +/- 2.3 to 6.7 +/- 0.8 IU/l; P < 0.001) but plasma insulin concentrations remained unchanged following ovulation (14.6 +/- 1.9 and 15.7 +/- 3.8 pmol/l during amenorrhoea and after ovulation respectively). The results of this study suggest that chronic anovulation per se appears to modify the factors contributing to cellular insulin resistance seen in PCOS.


Publication metadata

Author(s): Marsden PJ, Murdoch AP, Taylor R

Publication type: Article

Publication status: Published

Journal: Human Reproduction

Year: 1999

Volume: 14

Issue: 9

Pages: 2216-2222

Print publication date: 01/09/1999

ISSN (print): 0268-1161

ISSN (electronic): 1460-2350

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/humrep/14.9.2216

DOI: 10.1093/humrep/14.9.2216


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share