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Lookup NU author(s): Dr Jonathan Wyllie
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Aims-To correlate the size and position of isolated ventricular septal defects with closure rate in a cohort of children with mean follow up of more than six years. Design-A birth cohort was identified using the northern region cardiac database. The following were noted from case notes: defect size, position, means of closure, and age at closure. Results-68 children were identified. 49 defects were small, 14 were moderate, and 5 were large. 13 cases required surgical closure, including 12 perimembranous defects. 35 defects closed spontaneously. Nine of the small muscular defects remained open and five of the small perimembranous defects remained open. The spontaneous closure rate for muscular defects was significantly greater than for perimembranous defects. Mean age of follow up for patients who still have defects is 76 months. Conclusions-The position of; a ventricular septal defect is extremely relevant to its natural history. Perimembranous defects accounted for most of the moderate and large defects that required surgical intervention. After more than six years almost a third of all perimembranous and just over two thirds of all muscular defects closed spontaneously.
Author(s): Turner SW, Hunter S, Wyllie JP
Publication type: Article
Publication status: Published
Journal: Archives of Disease in Childhood
Year: 1999
Volume: 81
Issue: 5
Pages: 413-416
Print publication date: 01/11/1999
ISSN (print): 0003-9888
ISSN (electronic): 1468-2044
Publisher: BMJ Group
URL: http://dx.doi.org/10.1136/adc.81.5.413
DOI: 10.1136/adc.81.5.413
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