Toggle Main Menu Toggle Search

Open Access padlockePrints

Unsuspected Pneumocystis carinii pneumonia at presentation of severe primary immunodeficiency

Lookup NU author(s): Dr Janet Berrington, Dr Terence Flood, Dr Mario Abinun, Dr Angela Galloway, Professor Andrew Cant


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background-Pneumocystis carinii is an important pathogen in immunodeficiency but may be an unrecognised cause of respiratory compromise. Objectives-To ascertain the incidence of P carinii pneumonia (PCP) at presentation of severe combined deficiency (SCID), whether it had been diagnosed, and the effect of treatment on outcome. Setting-The supraregional paediatric bone marrow transplant unit for primary immunodeficiencies at Newcastle General Hospital. Methods-Retrospective case note review of infants referred with a diagnosis of SCID from 1992 to 1998. Results-Ten of 50 infants had PCP at presentation; only one was diagnosed before transfer. Eight were diagnosed by bronchoalveolar lavage and two by lung biopsy. In only one was P carinii identified in nasophapyngeal secretions. Five required ventilation for respiratory failure but all were successful treated with co-trimoxazole and methylprednisolone with or without nebulised budesonide. Nine survived to bone narrow transplantation and four are long term survivors after bone marrow transplantation; no deaths were related to PCP. Conclusions-PCP is a common presenting feature of SCID but is rarely recognised. Bronchoalveolar lavage or lung biopsy are needled for diagnosis. Treatment with co-trimoxazole is highly successful.

Publication metadata

Author(s): Berrington JE, Flood TJ, Abinun M, Galloway A, Cant AJ

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2000

Volume: 82

Issue: 2

Pages: 144-147

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Publishing Group Ltd