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Intracellular copper routing: the role of copper chaperones

Lookup NU author(s): Dr Dr MD Harrison Harrison


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Copper is required by all living systems. Cells have a variety of mechanisms to deal with this essential, yet toxic trace element. A recently discovered facet of homeostatic mechanisms is the protein-mediated, intracellular delivery of copper to target proteins. This routing is accomplished by a novel class of proteins, the 'copper chaperones'. They are a family of conserved proteins present in prokaryotes and eukaryotes, which suggests that copper chaperones are used throughout nature for intracellular copper routing.

Publication metadata

Author(s): Harrison MD, Jones CE, Solioz M, Dameron CT

Publication type: Review

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 2000

Volume: 25

Issue: 1

Pages: 29-32

ISSN (print): 0968-0004

ISSN (electronic): 0167-7640


DOI: 10.1016/S0968-0004(99)01492-9