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Lookup NU author(s): Dr Martin Ward Platt
Aims-To investigate patterns of infant growth that may influence the risk of sudden infant death syndrome (SIDS). Design-Three year population based case control study with parental interviews for each death and four age matched controls. Growth was measured from prospective weight observations using the British 1990 Growth Reference. Setting-Five regions in England (population greater than 17 million, more than 470 000 live births over three years). Subjects-247 SIDS cases and 1110 controls. Results-The growth rate from birth to the final weight observation was significantly poorer among the SIDS infants despite controlling for potential confounders (SIDS mean change in weight z score (delta zw) = -0.38 (SD 1.40) v controls = +0.22 (SD 1.10), multivariate: p < 0.001). Weight gain was poorer among SIDS infants with a normal birth weight (above the 16th centile: odds ratio (OR) = 1.75, 95% confidence interval (CI) 1.48-2.07, p < 0.0001) than for those with lower birth weight (OR = 1.09, 95% CI 0.61-1.95, p = 0.76). There was no evidence of increased growth retardation before death. Conclusions-Poor postnatal weight gain was independently associated with an increased risk of SIDS and could be identified at the routine six week assessment.
Author(s): Blair PS, Nadin P, Cole TJ, Fleming PJ, Smith IJ, Ward Platt M, Berry PJ, Golding J, CESDI SUDI Research Group
Publication type: Article
Publication status: Published
Journal: Archives of Disease in Childhood
Year: 2000
Volume: 82
Issue: 6
Pages: 462-468
ISSN (print): 0003-9888
ISSN (electronic): 1468-2044
Publisher: BMJ Group
URL: http://dx.doi.org/10.1136/adc.82.6.462
DOI: 10.1136/adc.82.6.462
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