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Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE

Lookup NU author(s): Professor David Burn, Dr Uma Nath, Sarah Daniel


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Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha -synuclein, synphilin, or APOE variability on the development of PSP, or of tan, alpha -synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.

Publication metadata

Author(s): Morris HR, Vaughan JR, Datta SR, Bandopadhyay R, de Silva HAR, Schrag A, Cairns NJ, Burn D, Nath U, Lantos PL, Daniel S, Lees AJ, Quinn NP, Wood NW

Publication type: Letter

Publication status: Published

Journal: Neurology

Year: 2000

Volume: 55

Issue: 12

Pages: 1918-1920

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X