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Sex and ageing

Lookup NU author(s): Emeritus Professor Thomas Kirkwood

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Abstract

Sex and ageing are often linked, particularly in the context of the evolutionary theories of ageing, which suggest that senescence may be the price for investing ire offspring at the expense of somatic maintenance and repair. Considerable evidence supports this concept although, strictly, it is not sex per se but the existence of the soma/germ-line distinction that appears to hold the key. Other aspects of the sex-ageing axis seeing exciting new developments are the evolution of the human life history, particularly with respect to menopause, and the molecular mechanisms that sustain the immortality of the germ-line in contrast to the cumulative damage that appears to underlie the ageing of somatic cells. (C) 2001 Elsevier Science Inc. All rights reserved.

Publication metadata

Author(s): Kirkwood TBL

Publication type: Review

Publication status: Published

Journal: Experimental Gerontology

Year: 2001

Volume: 36

Issue: 3

Pages: 413-418

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

URL: http://dx.doi.org/10.1016/S0531-5565(00)00255-2

DOI: 10.1016/S0531-5565(00)00255-2

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