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Lookup NU author(s): Dr Robert Barber, Professor Ian McKeith, Dr Clive Ballard, Dr Anil Gholkar OBE, Professor John O'Brien
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Objectives: To compare medial and lateral temporal lobe atrophy on magnetic resonance imaging (MRI) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), and to examine the relationship between volumetric indices and cognitive and non-cognitive symptoms. Methods: T-1-weighted 1.0-tesla MRI scans were acquired in elderly subjects with DLB (n = 26; mean age = 75.8 years) and AD (n = 22; 77.3 years) and normal controls (n = 26; 76.2 years). MRI-based volume measurements of the hippocampus, parahippocampus, fusiform gyrus, combined inferior and middle temporal gyri, and superior temporal gyrus were acquired. Results: Hippocampal and parahippocampal volumes were significantly larger in subjects with DLB compared to AD. Differences in hippocampal volumes between DLB and AD were observed across the entire length, and in all subjects with dementia there was a loss of hippocampal asymmetry compared to normal controls. Atrophy of temporal lobe structures correlated with memory impairment in both groups, and with age in DLB, There was no association between atrophy and psychotic symptoms in either group. Conclusions: Subjects with DLB and AD have a different pattern of temporal lobe atrophy with the most striking differences relating to medial rather than lateral temporal lobe structures. These structural differences could explain the relative preservation of memory function in DLB compared to AD. Copyright (C) 2001 S. Karger AG, Basel.
Author(s): Gholkar A; McKeith IG; O'Brien JT; Barber R; Ballard C
Publication type: Article
Publication status: Published
Journal: Dementia and Geriatric Cognitive Disorders
Year: 2001
Volume: 12
Issue: 3
Pages: 198-205
ISSN (print): 1420-8008
ISSN (electronic): 1421-9824
Publisher: S Karger AG
URL: http://dx.doi.org/10.1159/000051258
DOI: 10.1159/000051258
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