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The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin

Lookup NU author(s): Professor William Clegg, Dr Mark Elsegood

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Abstract

A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity. (C) 2001 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Murray PJ, Kranz M, Ladlow M, Taylor S, Berst F, Holmes AB, Keavey KN, Jaxa-Chamiec A, Seale PW, Stead P, Upton RJ, Croft SL, Clegg W, Elsegood MRJ

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry Letters

Year: 2001

Volume: 11

Issue: 6

Pages: 773-776

ISSN (print):

ISSN (electronic): 1464-3405

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0960-894X(01)00049-X

DOI: 10.1016/S0960-894X(01)00049-X

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