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Lookup NU author(s): Emeritus Professor Bill Clegg,
Dr Mark Elsegood
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A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity. (C) 2001 Elsevier Science Ltd. All rights reserved.
Author(s): Murray PJ, Kranz M, Ladlow M, Taylor S, Berst F, Holmes AB, Keavey KN, Jaxa-Chamiec A, Seale PW, Stead P, Upton RJ, Croft SL, Clegg W, Elsegood MRJ
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry Letters
ISSN (electronic): 1464-3405
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