Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin

Lookup NU author(s): Professor William Clegg, Dr Mark Elsegood

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity. (C) 2001 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Murray PJ, Kranz M, Ladlow M, Taylor S, Berst F, Holmes AB, Keavey KN, Jaxa-Chamiec A, Seale PW, Stead P, Upton RJ, Croft SL, Clegg W, Elsegood MRJ

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry Letters

Year: 2001

Volume: 11

Issue: 6

Pages: 773-776

ISSN (print):

ISSN (electronic): 1464-3405

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0960-894X(01)00049-X

DOI: 10.1016/S0960-894X(01)00049-X

Altmetrics

Altmetrics provided by Altmetric

Share