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Peri-operative risk factors for acute lung injury after elective oesophagectomy

Lookup NU author(s): Andrew Batchelor, Dr Robert Bullock, Dr Alistair Gascoigne, Mark Griffin, Nick Hayes, Jeremy Hing, Ian Shaw, Dr Ian Warnell, Dr Simon Baudouin


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Acute lung injury after oesophagectomy is well recognized but the risk factors associated with its development are poorly defined. We analysed retrospectively the effect of a number of pre-, peri- and post-operative risk factors on the development of lung injury in 168 patients after elective oesophagectomy performed at a single centre. The acute respiratory distress syndrome (ARDS) developed in 14.5% of patients and acute lung injury in 23.8%. Mortality in patients developing ARDS was 50% compared with 3.5% in the remainder. Features associated with the development of ARDS included a low pre-operative body mass index, a history of cigarette smoking, the experience of the surgeon, the duration of both the operation and of one-lung ventilation, and the occurrence of a post-operative anastomotic leak. Peri-operative cardiorespiratory instability (measured by peri-operative hypoxaemia, hypotension, fluid and blood requirements and the need for inotropic support) was also associated with ARDS. Acute lung injury after elective oesophagectomy is associated with intraoperative cardiorespiratory instability.

Publication metadata

Author(s): Griffin M; Gascoigne A; Warnell I; Batchelor A; Baudouin SV; Hing J; Bullock R; Tandon S; Hayes N; Shaw I

Publication type: Article

Publication status: Published

Journal: British Journal of Anaesthesia

Year: 2001

Volume: 86

Issue: 5

Pages: 633-638

ISSN (print): 0007-0912

ISSN (electronic): 1471-6771

Publisher: Oxford University Press


DOI: 10.1093/bja/86.5.633


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