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Lookup NU author(s): Professor Kim Bartlett
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Carnitine palmitoyltransferase I is assumed to be rate limiting for beta -oxidation in all tissues. However, the concentration of molonyl-CoA in heart and muscle is high and is enough to completely inhibit beta -oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta -oxidation in the heart.
Author(s): Eaton S, Fukumoto K, Duran NP, Pierro A, Spitz L, Quant PA, Bartlett K
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Biochemical Society Transactions: Colloquium on Fatty Acid Oxidation and Ketone Body Metabolism
Year of Conference: 2001
Publisher: Portland Press Ltd.
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