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Lookup NU author(s): Professor John SayerORCiD,
Professor Simon PearceORCiD
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Epithelial ion channels and transporter proteins have physiologically important roles throughout the length of the nephron. Discovering the molecular identities of tubular epithelial cell proteins and their functional roles has increased understanding of both renal physiology and tubular diseases. Defects in tubular handling of solutes may present with nephrocalcinosis or nephrolithiasis, rickets, acid-base, electrolyte or blood pressure disturbances. Biochemical analysis of both serum and urine, together with clinical history and examination, remain fundamental for their diagnosis, whilst understanding of underlying molecular mechanisms allows appropriate management.
Author(s): Sayer JA; Pearce SHS
Publication type: Review
Publication status: Published
Journal: Annals of Clinical Biochemistry
ISSN (print): 0004-5632
ISSN (electronic): 1758-1001