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The ischaemic lactate-ammonia test

Lookup NU author(s): Professor Patrick Chinnery, Emeritus Professor Doug Turnbull


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The ischaemic lactate ammonia test is widely used for investigating patients with Muscle pain and fatigue, It involves measuring plasma lactate and ammonia produced its a result of forearm exercise under ischaemic conditions ill a fasted subject. Its clinical use is to screen patients with muscle complaints for disorders of carbohydrate metabolism. in particular to identify those in whom further investigation may provide useful diagnostic information. There is a wide variety of methods described. reflecting attempts to optimize the response and hence the diagnostic Value of the test. Although it is often considered a general screening test for metabolic muscle disease, the Situations ill Which it is Useful are specific. Here we review the use of the test and present the results of an audit of its use in our departments.

Publication metadata

Author(s): Chinnery PF; Turnbull DM; Livingstone C

Publication type: Review

Publication status: Published

Journal: Annals of Clinical Biochemistry

Year: 2001

Volume: 38

Issue: 4

Pages: 304-310

ISSN (print): 0004-5632

ISSN (electronic): 1758-1001


DOI: 10.1258/0004563011900786