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QT prolongation in patients with Type 2 diabetes and microalbuminuria

Lookup NU author(s): Dr Janet McComb, Dr Patrick Kesteven, Emerita Professor Sally Marshall


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The link between microalbuminuria and premature death in Type 2 diabetes is not fully explained by conventional cardiovascular risk factors. We aimed to determine if QT prolongation and/or dispersion are linked to microalbuminuria in patients with Type 2 diabetes and to investigate their associations with other risk factors. We have studied asymptomatic patients with Type 2 diabetes with no clinical evidence of coronary disease (43 with microalbuminuria matched with 43 normoalbuminuric patients). Rate-corrected maximum QT interval (QT(c) max) was greater in the microalbuminuric group [mean (SD): 450 (23) vs 440 (20) ms(1/2), p = 0.046] as was the proportion of patients with QT(c) max > 440 ms (67% vs 38%, p = 0.01). Rate-corrected QT dispersion (QT(cd)) was similar in the two groups [57 (21) vs 53 (23) ms(1/2), p = 0.41]. Linear regression analysis showed that QT(c) max and/or QT(cd) were not strongly linked to albumin excretion rate but more strongly to factors associated with micro albuminuria such as blood pressure and factor XIIa. Our findings support the hypothesis that QT prolongation and microalbuminuria have common determinants in Type 2 diabetes. QT prolongation may contribute to the increased mortality observed in microalbuminuric subjects with Type 2 diabetes.

Publication metadata

Author(s): Marshall SM; McComb JM; Kesteven P; Rutter MK; Viswanath S

Publication type: Article

Publication status: Published

Journal: Clinical Autonomic Research

Year: 2002

Volume: 12

Issue: 5

Pages: 366-372

ISSN (print): 0959-9851

ISSN (electronic): 1619-1560

Publisher: Dr. Dietrich Steinkopff Verlag


DOI: 10.1007/s10286-002-0036-8


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