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Lookup NU author(s): Dr Carmen Martin-RuizORCiD, Dr Margaret Piggott, Dr Mark Cookson, Emeritus Professor Robert Perry, Dr Evelyn Jaros, Emeritus Professor Elaine Perry, Dr Jennifer Court
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A reduction in nicotinic receptor (nAChR) binding has previously been observed in putamen in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The present study demonstrates no concommitant reduction in the expression of alpha2-alpha7, beta2 and beta3 nAChR subunit proteins. Alphasynuclein, which can interfere with membrane protein function and is a key constituent of PD and DLB pathology, was increased (insoluble fraction) in both disorders, although nAChR binding loss did not correlate with a-synuclein expression within patient groups. The results point to a possible abnormality of striatal nicotinic receptor assembly in PD and DLB. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Author(s): Piggott M; Perry RH; Cookson MR; Perry EK; Court JA; Martin-Ruiz C; Lawrence S; Kuryatov A; Lindstrom J; Gotti C; Jaros E
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Year: 2002
Volume: 335
Issue: 2
Pages: 134-138
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
Publisher: Elsevier Ireland Ltd
URL: http://dx.doi.org/10.1016/S0304-3940(02)01183-7
DOI: 10.1016/S0304-3940(02)01183-7
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