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Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage

Lookup NU author(s): Emeritus Professor Tim Cawston, Emeritus Professor Drew Rowan


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Oncostatin M (OSM) in combination with turnout necrosis factor alpha (TNFalpha) promotes marked collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases and cool be prevented by transforming growth factor beta1 (TGFbeta1) or insulin-like growth factor 1. Both growth factors, reduced the expression and secretion of collagenase enzymes, and TGFbeta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against OSM+TNFalpha induced destruction.

Publication metadata

Author(s): Hui W, Cawston TE, Rowan AD

Publication type: Article

Publication status: Published

Journal: Annals of the Rheumatic Diseases

Year: 2003

Volume: 62

Issue: 2

Pages: 172-174

ISSN (print): 0003-4967

ISSN (electronic): 1468-2060

Publisher: BMJ Group


DOI: 10.1136/ard.62.2.172


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