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Lookup NU author(s): Emeritus Professor Tim Cawston,
Emeritus Professor Drew Rowan
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Oncostatin M (OSM) in combination with turnout necrosis factor alpha (TNFalpha) promotes marked collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases and cool be prevented by transforming growth factor beta1 (TGFbeta1) or insulin-like growth factor 1. Both growth factors, reduced the expression and secretion of collagenase enzymes, and TGFbeta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against OSM+TNFalpha induced destruction.
Author(s): Hui W, Cawston TE, Rowan AD
Publication type: Article
Publication status: Published
Journal: Annals of the Rheumatic Diseases
ISSN (print): 0003-4967
ISSN (electronic): 1468-2060
Publisher: BMJ Group
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