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Loss of muscarinic M-4 receptors in hippocampus of Alzheimer patients

Lookup NU author(s): Professor Raj KalariaORCiD

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Abstract

We assessed muscarinic M-1, M-2 and M-4 receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [I-125]muscarinic toxin-1 ([I-125]MT-1, M, selective). [H-3]AFDX-384 (M-2 partially selective) and [I-125]muscarinic toxin 4 ([I-125]M-4 toxin-1, M-4 selective). Our results revealed a significant decrease in muscarinic M-4 receptor binding in the dentate gyrus and CA4 regions of brain sections from Alzheimer's patients compared to controls. No changes in the density of M-1 or M, receptor binding were observed. Our findings suggest that, relative to other muscarinic receptor subtypes, the M-4 receptor could be the subtype which is selectively compromised in Alzeheimer's disease (AD). (C) 2002 Published by Elsevier Science B.V.

Publication metadata

Author(s): Mulugeta E, Karlsson E, Islam A, Kalaria R, Mangat H, Winblad B, Adem A

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 2003

Volume: 960

Issue: 1-2

Pages: 259-262

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/S0006-8993(02)03542-4

DOI: 10.1016/S0006-8993(02)03542-4

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