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Spontaneous clinical improvement in HIV-associated follicular syndrome

Lookup NU author(s): Dr Niamh Leonard, Dr Edmund Ong, Dr Clifford Lawrence


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Since 1991 infrequent reports have described a distinctive triad of nodulocystic acne, striking follicular spines and an eruption resembling pityriasis rubra pilaris (PRP) in HIV-positive patients. It has been suggested that this may represent a subtype of PRP, or alternatively that it should be viewed as a unique HIV-associated follicular occlusion triad. Clinical manifestations may be severe, and in several cases have been ultimately fatal, with death occurring due to complications of cutaneous sepsis. We describe a case demonstrating severe conglobate acne, follicular keratotic spines and histologically confirmed PRP in association with HIV infection. Clinical features and treatment modalities of previously reported cases are reviewed. Despite refusing all topical and systemic treatment our patient showed spontaneous remission of skin signs after 2 years.

Publication metadata

Author(s): Blasdale C, Turner RJ, Leonard N, Ong ELC, Lawrence CM

Publication type: Article

Publication status: Published

Journal: Clinical and Experimental Dermatology

Year: 2004

Volume: 29

Issue: 5

Pages: 480-482

ISSN (print): 0307-6938

ISSN (electronic): 1365-2230

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1365-2230.2004.01571.x


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