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Lookup NU author(s): Thanasak Teaktong CBE, Dr Alison Graham, Dr Jennifer Court, Emeritus Professor Robert Perry, Dr Evelyn Jaros, Mary Johnson, Emeritus Professor Elaine Perry
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Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are common forms of dementia in the elderly. The neuropathology of AD and DLB is related to cholinergic dysfunctions, and both alpha4 and alpha7 nicotinic acetylcholine receptor (nAChR) subunits are decreased in several brain areas in both diseases. In this immunohistochemical study, we compared neuronal and astroglial alpha4 and alpha7 subunits in AD, DLB and age-matched controls in the hippocampal formation. The numbers of alpha4 reactive neurons were decreased in layer 3 of the entorhinal cortex of AD and DLB, whereas those of alpha7 reactive neurons were decreased in layer 2 of the subiculum of AD and DLB and in layer 3 of the entorhinal cortex of DLB. In contrast, the intensity of alpha7 reactive neuropil was significantly higher in AD than in controls or DLB in a number of areas of the hippocampus (CA3/4 and stratum granulosum), subiculum and entorhinal cortex. An increase in alpha7 immunoreactivity in AD was also associated with astrocytes. The number of astrocytes double-labelled with alpha7 and glial fibrillary acidic protein (GFAP) antibodies was increased in most areas of the hippocampus and entorhinal cortex in AD compared with controls and DLB. Increased astrocyte alpha7 nAChRs in AD may be associated with inflammatory mechanisms related to degenerative processes specific to this disease. (C) 2004 Elsevier B.V. All rights reserved.
Author(s): Teaktong T, Graham AJ, Court JA, Perry RH, Jaros E, Johnson M, Hall R, Perry EK
Publication type: Article
Publication status: Published
Journal: Journal of the Neurological Sciences
Year: 2004
Volume: 225
Issue: 1-2
Pages: 39-49
ISSN (print): 0022-510X
ISSN (electronic): 1878-5883
Publisher: Elsevier
URL: http://dx.doi.org/10.1016/j.jns.2004.06.015
DOI: 10.1016/j.jns.2004.06.015
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