Toggle Main Menu Toggle Search

Open Access padlockePrints

Factors influencing early failure of central venous catheters in children with cancer

Lookup NU author(s): Andrew Barrett, Dr Kevin Windebank


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background: The authors report the results of a prospective, multicenter, multidisciplinary study of central venous catheters (CVCs) in pediatric oncology patients analyzing factors involved in early failure. Methods: Information was collected from parent-held records on the fate of 824 devices inserted over a 20-month period, 415 of which were no longer in situ. Results:Within the first 7 weeks after insertion, there were 66 failures, all occurring in external lines. Accidental dislodgement was the principal reason for CVC failure (44 of 66, 67%). Detailed analysis of the reason for failure of this large subgroup showed 11 factors individually associated with early dislodgement, of which, 4 were independently associated with failure by multivariate analysis. These 4 variables were the use of multilumen catheters, the absence of a skin exit site suture, platelet transfusion at the time of insertion, and patient age less than 2 years. Conclusions: This study confirms the multiple influences on successful CVC usage. Our analysis supports the principle of only using multilumen lines when clinically essential. The findings also support the inception of randomized studies of fixation, particularly in infants. (C) 2004 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Barrett M, Imeson J, Leese D, Philpott C, Shaw ND, Pizer BL, Windebank KP, United Kingdom Childrens Cancer

Publication type: Article

Publication status: Published

Journal: Journal of Pediatric Surgery

Year: 2004

Volume: 39

Issue: 10

Pages: 1520-1523

ISSN (print): 0022-3468

ISSN (electronic): 1531-5037

Publisher: WB Saunders Co.


DOI: 10.1016/j.jpedsurg.2004.06.020


Altmetrics provided by Altmetric