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Intrinsic ageing of gut epithelial stem cells

Lookup NU author(s): Emeritus Professor Thomas Kirkwood


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The maintenance of integrity of gut epithelium is essential for the well being of the organism throughout life. Gut epithelium is maintained through a carefully controlled balance between cell loss and renewal, which is sustained by the proliferation of the epithelial stem cells. Although these stem cells show no intrinsic limit to their proliferative capacity, recent evidence indicates that they suffer important functional impairments during the course of ageing. This paper reviews what is currently known about intrinsic ageing of gut epithelial stem cells and its functional consequences. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Kirkwood TBL

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2004

Volume: 125

Issue: 12

Pages: 911-915

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland


DOI: 10.1016/j.mad.2004.09.004


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Funder referenceFunder name
BEP17042Biotechnology and Biological Sciences Research Council