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Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin

Lookup NU author(s): Dr Kevin Windebank, Dr Michael Lowry, Professor Andrew Pearson


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Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of nonfamilial HLH.

Publication metadata

Author(s): Estlin EJ, Palmer RD, Windebank KP, Lowry MF, Pearson ADJ

Publication type: Article

Publication status: Unknown

Journal: Archives of Childhood Diseases

Year: 1996

Volume: 75

Issue: 5

Pages: 432-435

Print publication date: 01/11/1996

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Publishing


DOI: 10.1136/adc.75.5.432


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