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The influence of ifosfamide scheduling on acute nephrotoxicity in children

Lookup NU author(s): Professor Roderick Skinner, Professor Andrew Pearson, Emeritus Professor Alan Craft


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Nephrotoxicity is a significant problem in children after treatment with ifosfamide. Acute changes in renal function were compared in 16 children receiving 9 g m(-2) of ifosfamide as a 72-h continuous infusion on one occasion and, on another course, divided into three I-h infusions on consecutive days. Subclinical acute nephrotoxicity was demonstrated with both schedules, but there were no significant differences in severity.

Publication metadata

Author(s): English, M. W., Skinner, R., Pearson, A. D. J., Price, L., Wyllie, R., Craft, A. W.

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1997

Volume: 75

Issue: 9

Pages: 1356-1359

Print publication date: 01/05/1997

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

PubMed id: 9155058