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Lookup NU author(s): Dr Jennifer Court,
Dr Michael Griffiths,
Dr Margaret Piggott,
Emeritus Professor Elaine Perry,
Emeritus Professor Robert Perry
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High-affinity nicotine, alpha-bungarotoxin (alpha BT) and muscarinic receptor binding was measured in the human hippocampal formation in a series of 57 cases aged between 24 weeks gestation and 100 years. Changes in nicotine receptor binding during development and aging were more striking than differences in alpha BT and muscarinic binding. Nicotine binding was higher at the late foetal stage than at any other subsequent time in all areas investigated. In the hippocampus a fall in binding then occurred within the first six months of life, with little or no subsequent fall during aging, whereas in the entorhinal cortex and the presubiculum the major loss of nicotine binding occurred after the fourth decade. alpha BT binding was significantly elevated in the CA 1 region, but in no other region of the hippocampus, in the late foetus, and there was also a fall in alpha BT binding in the entorhinal cortex during aging from the second decade. The modest changes in total muscarinic binding, which appeared to reflect those in M1 and M3 + 4 rather than M2 binding, were a rise in the entorhinal cortex between the foetal stage and childhood and a tendency for receptors to fall with age in the hippocampus and subicular complex. These findings implicate mechanisms controlling the expression of nicotinic receptors to a greater extent than muscarinic receptors in postnatal development and aging in the human hippocampus. (C) 1997 Elsevier Science B.V.
Author(s): Piggott MA; Perry RH; Perry EK; Lloyd S; Court JA; Griffiths M; Oakley AE; Johnson M; Birdsall NJM; Ince PG
Publication type: Review
Publication status: Published
Journal: Developmental Brain Research
Print publication date: 01/07/1997
ISSN (print): 0165-3806
ISSN (electronic): 1872-6755
PubMed id: 9263584