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Anti-vimentin antibody detection in recipients of heart-beating and non-heart beating donor kidneys

Lookup NU author(s): John Asher, Dr Brian Shenton, Susan Stamp, Muhammed Gok, David Talbot


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Alternative donor sources include non-heart-beating donors (NHBDs). There donors have been exposed to significant ischemia, so that it is common to utilize machine perfusion to either improve the organs or at least assess their viability. Both prolonged warm ischemia and machine perfusion can potentially damage the vascular endothelium, thereby exposing vimentin to antigenic recognition. The aim of this study was to determine whether anti-vimentin antibodies could be detected in the blood of renal transplant recipients at specific time points after transplant and whether they could be related to the donor source. Fifty-one recipients of NHBD kidneys were compared to 52 recipients of heart-beating donor (HBD) kidneys. All recipients had similar anti-vimentin levels pretransplant. However, at 1 month those kidneys from Maastricht category II NHB donors showed significantly higher levels. At 6 months both Maastricht category II and category III NHB donor recipients displayed significantly higher levels than recipients of HBD kidneys.

Publication metadata

Author(s): Mi H, Carter V, Gupta A, Asher J, Shenton B, Stamp S, Wong YT, Gok MA, Talbot D

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Transplantation Proceedings: 22nd Congress of the Scandinavian Transplantation Society

Year of Conference: 2005

Pages: 3269-3271

ISSN: 0041-1345

Publisher: Elsevier Inc.


DOI: 10.1016/j.transproceed.2005.09.062

Library holdings: Search Newcastle University Library for this item

ISBN: 18732623